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Neurotoxicology 46, 101116

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The total of four conversions of NAD + to NADH in the joint glutamate synthesis/oxidation process suggested [two in astrocytes during the production of -ketoglutarate and one during glutamate oxidation (Figure 3B), together with one in neurons (Figure 5)] may explain the close to 1:1 ratio between rates of glucose oxidation and of glutamine/glutamate (GABA) cycle flux

oxygen radicals can cause cell mutations, and Glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase are scavengers of free radicals and reactive oxygen species in the body while protecting the membrane system of cells from damage and preventing cell carcinogenesis

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