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The observed shift toward immature (neutral) mucins during demyelination, followed by a restoration of more mature (acidic) mucins during remyelination, suggests a finely tuned regulation of mucus maturation aimed at re-establishing barrier integrity ( SCFAs are key mediators of intestinal homeostasis, known to promote goblet cell differentiation and mucus production ( in vitro ( Dubosiella newyorkensis during remyelination, previously linked to rebalancing the Th17/Treg axis and redirecting tryptophan metabolism toward the kynurenine pathway, thereby reducing the production of neurotoxic indoxyl sulfate ( D

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Trends Endocrinol Metab 16 : 190197 Yuen K et al

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