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8-OHdG can mispair with adenine during DNA replication, leading to G to T transversions

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This is where the link between MTHFR gene mutation, preconception and pregnancy arises

J Biol Chem 280:2557125579 Koehler RC, Roman RJ, Harder DR (2009) Astrocytes and the regulation of cerebral blood flow

The ability of G/D-CuP to scavenge reactive oxygen species (ROS) was evaluated by conducting Fenton-like reactions where hydrogen peroxide (H 2 O 2 ) generates reactive hydroxyl radicals (OH) with the help of metal catalysts, leading to significant oxidative harm 65