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Murray F, Patel HH, Suda RY, Zhang S, Thistlethwaite PA, Yuan JX, et al

High glucose-induced endothelial STING activation inhibits diabetic wound healing through impairment of angiogenesis

Cells generate localized ROS near the nuclear envelope (NOX isoforms), the outer mitochondrial membrane (MAO facing the cytosol) and cytosolic dehydrogenase complexes adjoining the nucleus (Kaludercic et al

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However, when it was tested in humans, it worsened stroke outcome and was associated with ICH, cardiac arrest, and meningitis [113,129]