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Systemic symptoms such as fever, chills, or malaise following injection warrant immediate medical evaluation

[PubMed: 11825646] 192

The ominous octet (Defronzo model) includes: decreased muscle glucose uptake, increased hepatic glucose output, impaired incretin effect, alpha-cell hyperglucagonemia, increased renal glucose reabsorption (SGLT-2 upregulation), increased lipolysis (adipose), decreased central satiety signaling, and decreased beta-cell insulin secretion

It is not the fault of the trainee doctor or nurse that this vital education is missing but countless patients have provided a valuable opportunity for CPD by providing information for those in qualified to be in charge of their care

That makes them far more effective than oral supplements, especially for patients managing deficiencies, chronic fatigue, or general low energy