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Also it occurs at an activated carbon atom, that is next to sp , sp2 carbons: Oxidative Phase-I involving cytochrome P-450 enzymes: Aromatic hydroxylation: Oxidative Phase-I involving cytochrome P-450 enzymes: Alkene epoxidation: Glutathione conjugation For electrophilic drugs and metabolites: Glutathione conjugation Toxicity of aromatic compounds came from the formation of arene oxide during the metabolism that will be attacked by endogenous nucleophile such as proteins, DNA or RNA

Under normal, healthy conditions, BCAAs and another amino acid called tryptophan compete with each other to cross the blood-brain barrier via the same transport proteins

There are also reports of ebselen conjugates with commonly used drugs, such as clioquinol, a compound known for its ability to chelate metal ions and inhibit A deposition

Medical screening required.