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High refined carbohydrate intake (worsens methyl donor deficiency)

Preclinical work has demonstrated that activation of mu opioid receptors (MORs) is necessary, but not sufficient for ketamine to reduce depressive-like behaviors 17 , that ( S )-ketamine involves direct interactions with brain MORs at doses and concentrations relevant to its reinforcement and antidepressant-like efficacy 18 , and that -endorphin presence and opioid receptor activation in the mPFC may be required for ketamines antidepressant actions 19

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10.1016/j.clinbiochem.2007.03.014PubMed Abstract | CrossRef Full Text | Google Scholar 7 ForoumadiA.RinehA.EmamiS.SiavoshiF.MassarratS.SafariF.et al (2008)