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Plant Cell Environ 35:454484 Noshi M, Hatanaka R, Tanabe N, Terai Y, Maruta T, Shigeoka S (2016) Redox regulation of ascorbate and glutathione by a chloroplastic dehydroascorbate reductase is required for high-light stress tolerance in Arabidopsis

Because cardiomyocytes are terminal differentiated cells, their loss in heart failure is irreversible, therefore, preventing cardiomyocyte hypertrophy and death is of great physiological significance for maintaining heart function and delaying heart failure

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For example, an abnormal increase in Fe 2+ in lysosomes and endoplasmic reticulum has been observed before the death of HT1080 cells induced by erastin using a variety of novel fluorescent probes ( Figure 4 ) (Hirayama et al., 2019)