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In addition to NADPH oxidase, several other enzymes may contribute to ROS generation, including xanthine oxidase, NO synthase (NOS) and mitochondrial enzymes

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Relaxin, on the other hand, enhances matrix metalloproteinase (MMP) activity, enzymes that degrade collagen and other extracellular matrix components, resulting in a more compliant ligament

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Zinc stimulates the MTs, functioning as cytoprotective agents and electrophilic scavengers, thereby alleviating oxidative stress-induced cellular damage