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Familial amyotrophic lateral sclerosis is the most illustrative example, since it is caused by a defect in the antioxidant enzyme superoxide dismutase gene

(1) Tissue viability assay : After overnight pre-incubation, the tissues were transferred to 6-well plates containing 2.5 ml/well fresh medium supplemented with vehicle (PBS) or MB at various concentrations from 0.1 M to 10 M

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Additionally, the integration of NPs with emerging epigenetic modulators and precision medicine approaches offers novel strategies to overcome current treatment limitations

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