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Despite strong evidence linking gut metabolites to the pathogenesis of CRC, several important limitations still impact our current understanding

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The mitochondria become sluggish, fragmented, and unable to meet the daily energy demands of the body, resulting in the debilitating, leaden fatigue that characterizes these conditions

For comparisons B and C, ORA was performed using the GOBP database 92 (release 2023) and the Reactome Pathway Knowledgebase 93 (release 2022) to identify over-represented pathways in the upregulated gene sets (padj 0.05 and padj 0.01, respectively)

This suggests combining ERO1 inhibition with ferroptosis inducers in the treatment of mTORC1-related cancer to achieve better outcomes