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23 NADPH is also needed for dihydrofolate reductase (DHFR) enzyme to catalyze the reduction of dihydrofolate to tetrahydrofolate (THF) in folate metabolism, which is required for de novo biosynthesis of thymidylate, purines, methionine, and some amino acids

The recommendation: choose one meal per day (breakfast, lunch, or dinner), dose 90-120 minutes before that meal, and maintain that schedule for the entire protocol duration

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Altogether, these findings support the idea that not only caffeine, but also other related components play a significant role in ameliorating behavioral and inflammatory parameters in anxiety and depression-like contexts