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10.1038/cmi.2015.95 Cell Mol Immunol

We next hypothesized that NADP oxidation during hypoxia may be due to NADPH consumption by the anti-oxidant machinery which is not matched by the rate of re-supply due to limitations in flux through central metabolism

Basics of MCAT Oxidation and Reduction Reactions MCAT Oxidation and Reduction Defined Oxidation: In essence, oxidation refers to the loss of electrons by an atom or molecule leading to a decrease in the oxidative state Reduction: On the other hand, reduction signifies the gain of electrons by an atom or molecule leading to a decrease in oxidative state