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2 Musclevasculature crosstalk in aging: an integrative perspective 2.1 Physiological interdependence between skeletal muscle and vascular endothelium The skeletal musculature and vascular systems exhibit a complex interdependence, constituting a dynamic physiological network that guarantees optimal tissue oxygenation, nutrient transport, and metabolic equilibrium

Although this metabolic pathway has been more extensively studied in tissues such as the liver, the unique high CYP1B1 environment in fibroid tissue suggests that local metabolism of E may constitute an intrinsic source of ROS [46]

doi: 10.1016/j.mehy.2013.11.013 307 BarzegariAKheyrolahzadehKHosseiniyan KhatibiSMSharifiSMemarMYZununi VahedS

8 Conclusion This review provides a comprehensive overview of the potential of MB in both basic research and clinical applications, with a particular emphasis on its innovative roles in disease diagnosis and therapy

10.1182/blood.2019000944 Blood