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Such resistance is the result of a process known as Redox Resetting 120,121 , where a new redox balance is established with a higher ROS level through the upregulation of the ROS-scavenging system, such as GPX7 , which can confer drug resistance 118,122,123,124

Mehrvarz Sarshekeh A, Loree J, Lima Pereira AA, Raghav KPS, Lam M, Advani SM, Davis JS, Dasari A, Morris VK, Menter D, Eng C, Shaw KR, Broaddus R, Routbort M, Luthra R, Maru DM, Overman MJ, Meric-Bernstam F, Kopetz S

Future studies should further use human-derived nervous system models or brain-like organs to more deeply explore the role of hormonal changes, inflammation, and neural network reorganization in the progression of insomnia, which will help to comprehensively reveal the complex pathological mechanism of insomnia and provide a more scientific basis for optimizing treatment strategies

Recent advances in understanding of pathogenesis of alcohol-associated liver disease

Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A