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Description

The crucial o-sulfonamidophenol group resides in the pocket created by the C-terminal helix and loop, forms a salt bridge with Gln207, and stabilizes its molecular conformation through - interactions with Trp8/206

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This range balances adequate pituitary stimulation against practical considerations of cost, side effect tolerance, and physiologic limitations

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These therapies are highly effective for advanced melanoma but frequently cause immune-related adverse events requiring corticosteroid management

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