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5.3 ATBs as double-edged microbiome modulators: metabolite-mediated impacts on cancer immunotherapy efficacy The role of ATBs in cancer immunotherapy embodies a context-dependent paradox, where their ability to alter gut and tumor-associated microbiota directly reshapes microbial metabolite profilesultimately dictating immunostimulatory or immunosuppressive outcomes

Moreover, Ig isotypes and subclasses (IgA, IgE, IgG1, IgG2a, IgG2b, IgG3 and IgM) were quantified with the Mouse Antibody Isotyping Panel 7-Plex (Invitrogen)

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In all cases, its use was a consensus decision between the treating cardiac surgeon and intensivist for patients requiring high or increasing doses of two or more vasoactive drugs to maintain adequate MAP (aiming over 65 mmHg)

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