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The index date was defined as the earliest date evidence of MASH was observed, and the study period was August 2016-November 2023

AT dysfunction manifests when expansion limits are reached, forcing lipid accumulation in non-ATs and triggering systemic metabolic deterioration (37, 261)

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Beyond GLP-1 and amylin pathways, modulation of the ghrelin axis [Figure 1] represents a promising avenue for future therapeutic development [21]

432 Minocycline, known to reduce microglial activation, reduces neuropathic pain in SpragueDawley rat models of T1DM with DPN