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4-Pantetheinylation of formyltetrahydrofolate dehydrogenase (FDH) The figure shows two reactions involving FDH: Panel A: Holo-FDH (the biologically active FDH) catalyzes the conversion of 10-formyltetrahydrofolate into tetrahydrofolate using water and NADP + , releasing CO 2 , NADPH, and a proton (H + )

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While a significant proportion of those infected with COVID-19 recover, a startling observation has emerged: more than 70% of survivors experience lingering symptoms 4 months post-infection, giving rise to what is now recognized as Long COVID Syndrome or post-acute sequelae SARS-CoV-2 infection (PASC) [1,2,3,4,5,6,7,8,9,10,11,12]