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Further studies have revealed delayed wound recovery in GPX4 siRNA-treated cells 2 days after wounding

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Key points noted from this experiment were (i) oxidative TCA cycle, the main mechanism for 13 C-citrate production in HUVEC cells, was increased upon ATMi, while reductive carboxylation decreased, and (ii) ATMi treatment resulted in more de novo GSH production without increasing overall GSH levels

coli SAM synthetase to reduce product inhibition and increase catalytic activity is a complementary strategy ( The L-carnitine biosensor fluorescence signal suggested high conversion of L-carnitine from intracellular TML (Figure 5B) as values were comparable to direct L-carnitine supplementation (Figure 6B), suggesting that the biosensor is sensitive to low intracellular L-carnitine levels and that the export of L-carnitine out of the E

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