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Statements Data availability statement The data sets presented in this study can be found in online repositories

We chose NRAS over BRAF because there is more frequent CDH1 downregulation in NRAS -mutant melanomas and a lack of targeted therapies for NRAS -mutated cases (Extended Data Fig

A 1% false discovery rate (FDR) was applied

Product information Directions : Take 1 capsules daily, 30 minutes before a meal or as directed by a health care professional

EC50 refers to the concentration of an antibody or an antigen-binding portion thereof or an immunoconjugate described herein, that induces a response, either in an in vitro or an in vivo assay, which is 50% of the maximal response, i.e., halfway between the maximal response and the baseline