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However, comprehensive safety data for the specific triple combination in humans is limited

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Additionally, HD has been shown to protect against Valproate-induced hepatotoxicity by its scavenging of free radicals, antioxidant property and prevent oxidative stress mediated apoptosis, as assessed by liver marker enzymes, oxidative stressors, antioxidant enzymes, mRNA and protein expression of apoptotic proteins (Nathiya et al., 2016)

Neuroinflammation appears to play a crucial role in these depressive-like phenotypes, particularly in regions such as the hippocampus, prefrontal cortex, anterior cingulate cortex and basolateral amygdala (Garcia et al., 2023)

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