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Their activation permits calcium influx and initiates intracellular signaling cascades involving calmodulin kinase II (CaMKII), cAMP Response Element Binding Protein (CREB) and MAPK, culminating in the transcription of genes required for long-lasting synaptic enhancement [208]

Pinna A, Ragaisyte I, Morton W, Angioletti-Uberti S, Proust A, DAntuono R, Luk CH, Gutierrez MG, Cerrone M, Wilkinson KA, Mohammed AA, McGilvery CM, Surez-Bonnet A, Zimmerman M, Gengenbacher M, Wilkinson RJ, Porter AE

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Prime editing, which employs a Cas9 nickase fused to reverse transcriptase along with a prime editing guide RNA, enables installation of all possible base transitions as well as small insertions and deletions without inducing DSBs