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However, sermorelins fidelity to the natural hormone comes with a tradeoff: it has a short half-life of approximately 1112 minutes in vivo and is susceptible to rapid enzymatic degradation

Science 287 , 20072010 (2000)

W.ShenH.TangX

10.1002/ar.24378 191 ShimadaK.SkoutaR.KaplanA.YangW

However, despite these studies showcasing the bioactivity of catechins, their clinical efficacy may be limited due to their low bioavailability in vivo