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Inhibition of KDM5A increases MPC1 expression in head and neck cancer DTCs, thereby reducing susceptibility to ferroptosis (31).Several drugs targeting the apoptotic pathway in DTCs have already been developed, such as ABT263, a specific inhibitor of the anti-apoptotic proteins BCL-2, BCL-W and BCL-XL, increasing the sensitivity of DTCs to drugs (32)

Comparing germ-free mice to conventionally grown (CONV-R) mice, it has been shown that the former had increased bone mass due to their changed immunological state, which includes lower pro-inflammatory cytokines, decreased CD4+ T cells, and fewer osteoclasts/precursors in the bone marrow (220)

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*Statistically significant difference from before treatment