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Interestingly, genetic inactivation of Hif1a and Hif2a significantly reduced the net phosphorylation of PDHA1 suggesting that residual HIF-1 activity under normoxic conditions may contribute to the regulation of basal PDH complex activity in neurons (Figure 2C)

We found that IGF-1 and IGF-1R were significantly upregulated in the gastrocnemius muscle of MTrPs rats

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