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For instance, omega-3 can prevent and reverse insulin resistance (IR) induced by a high-fat diet, improve glucose metabolism in patients with prediabetes (such as obese children or adults with metabolic syndrome), reduce systemic inflammation, and enhance metabolic flexibility (111)

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Despite limited investigation of sex and other biological variables potentially influencing ketamines opioid-dependent therapeutic efficacy, preliminary preclinical work suggests subanesthetic ketamine evokes opioid-mediated behavioral and neurophysiological effects in male but not female rats 46

Interestingly, a fraction of OPCs in the adult brain remain at the stage of immature progenitors and can respond to neuronal activity by proliferation and differentiation (Gibson et al., 2014), to adapt myelination to the needs of active networks