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The study by Clark et al

Enzymatic synthesis of (2 S ,3 S )- t -ES-Phe-amine The 15-ml reactions in 50 mM sodium phosphate buffer (pH 8.0) containing 2.0 mM 15 , 5.0 mM amine donor and 2.5 M Cp1D were performed at 30 C for 16 h

Such metabolic vulnerabilities suggest synergistic potential between ubiquitin-targeted drugs and dietary interventions like methionine restriction or serine/glycine deprivation