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Double knockout of Csnk1e on both alleles was accomplished using the Cre- loxP system

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Therapeutic interventions targeting the gut microbiota, such as probiotics, prebiotics, postbiotics, and fecal microbiota transplantation (FMT), have shown promise in restoring Treg-mediated immune homeostasis and ameliorating inflammation in both intestinal and extraintestinal contexts (88, 91)

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Secondary antioxidants are externally provided from dietary sources, such as vitamins (vitamins A, C and E), minerals (selenium, zinc, copper and manganese) and other substances, including polyphenols found in grapes and green tea