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These include potential immunogenicity, undefined long-term biosafety profiles of novel nanomaterials, suboptimal drug loading/release kinetics, limited penetration into the invasive tumor margin, and overcoming the immunosuppressive/hypoxic/acidic TME

doi: 10.1080/00362178185380411 140 Grogan LFR

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doi: 10.3390/cancers13112542 202 MatulaZMikalaGLukcsiSMatkJKovcsTMonostori

Primary cells and cell lines Primary human NK cells were isolated from blood donations collected from healthy individuals