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SAMe itself, as a methyl donor, is involved in the synthesis of creatine, epinephrine, melatonin, and the polyamines spermine and spermidine, among several other substances

This approach allows for early safety evaluation before broader cohort exposure

Effects of Methylsulfonylmethane (MSM) on exercise-induced oxidative stress, muscle damage, and pain following a half-marathon: a double-blind, randomized, placebo-controlled trial

Sze JH, Raninga PV, Nakamura K, Casey M, Khanna KK, Berners-Price SJ, Di Trapani G, Tonissen KF (2020) Anticancer activity of a gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma