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Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice

The compound significantly reduced lesion area in ethanol-induced and stress-induced models compared to controls, establishing the gastroprotective profile that would drive subsequent research (Sikiric et al., 1993, Journal of Physiology Paris

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[54] Fourteen systematic reviews of up to 353 participants suggest MDMA-assisted psychotherapy may substantially improve PTSD symptoms, response, and remission rates compared to psychotherapy alone, but the evidence is low to very low certainty and safety data are limited, with some increased transient adverse events

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