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A pioneer study gained insight in the mechanisms of formation of new inhibitory synapses on CA1 pyramidal cell dendrites in vitro using high resolution fluorescence confocal imaging of the sites of contact of inhibitory axons and postsynaptic structures (Wierenga et al., 2008)

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For deficiency, weekly injections are common during the loading phase, and monthly maintenance is standard long-term

It works by binding to the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary, triggering a calcium/PKC signaling cascade that releases stored growth hormone, while separately blunting somatostatin's inhibitory signal

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