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The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions

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Has a significant impact on cell growth and DNA synthesis

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In all cell models analyzed, tivantinib did not inhibit HGF-dependent or HGF-independent c-Met tyrosine autophosphorylation [85]