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PLoS ONE 15:e0244680

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On the other hand, although the primary goal of anti-PD therapy is to address T-cell exhaustion, when T-cell exhaustion is taken to extreme limits, anti-PD treatment may paradoxically promote the development of anti-PD resistance

10.1016/j.imbio.2016.06.013 161 MaxsonM

mTOR-activating mutations in RRAGD are causative for kidney tubulopathy and cardiomyopathy