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doi: 10.1111/j.1749-6632.2010.05627.x

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NAD + is also a cosubstrate for sirtuins (SIRTs), a family of signaling proteins involved in the regulation of cellular metabolic status, playing a key role in several processes such as mitochondrial function, DNA repair, and also activating metabolic pathways responsible for the detoxification of ROS (e.g., SOD, CAT, and isocitrate dehydrogenase 1) [240]