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Authors thank for financially supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2020R1I1A2066868), the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No

However, the high prevalence of VD deficiency in PD patients could also be the result of reduced outdoor activity owing to activity restriction, and the possibility that gastrointestinal dysfunction (a non-motor PD symptom) leads to lower VD2 levels in PD patients cannot be completely ruled out

These operate through completely different mechanisms

Tirzepatide's dual receptor mechanism How tirzepatide works: Dual GIP/GLP-1 receptor agonist Single molecule, two pathways GIP (glucose-dependent insulinotropic polypeptide) + GLP-1 Weekly subcutaneous injection FDA approved for diabetes and obesity GIP pathway effects: Enhances insulin secretion Improves insulin sensitivity Promotes fat metabolism Reduces inflammation Works synergistically with GLP-1 GLP-1 pathway effects: Suppresses appetite (central brain effects) Slows gastric emptying (moderate) Increases satiety Reduces glucagon Improves glucose control Combined tirzepatide results: 15-22% average body weight loss (monotherapy) Superior to semaglutide (GLP-1 alone) Well-tolerated in trials Approved and available See our tirzepatide dosing guide , semaglutide vs tirzepatide , and peptides for weight loss at SeekPeptides

Chen et al., also using NHANES, observed that HT patients following more pro-inflammatory diets showed higher TSH and TT4, though no significant association with thyroid antibodies was found [169]