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In addition, the observed differential 1-MNA steady-state levels following NNMT inhibition may reflect differential transcriptional regulation of cellular metabolic pathways across the various stages of 3T3-L1 differentiation;[38] for example, aldehyde oxidase (AOX)-mediated degradation of 1-MNA may be more pronounced in pre-adipocytes compared to adipocytes, thereby synergistically reducing 1-MNA levels to a greater extent in pre-adipocytes compared to adipocytes

However, despite its promising mechanisms, AOD-9604 is not FDA-approved for medical use

Not approved by the FDA.

This secretion increases metabolism, expediting fat burning and boosting energy levels

However, so far, no significant adverse effects have been consistently reported