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Role of the Keap1-Nrf2 System in Cytoprotection against Oxidative Stress To protect cells from harmful oxidative stress, the transcription factor Nrf2 plays an integrative role in inducing the expression of genes encoding enzymes involved in antioxidant (e.g., glutathione and NADPH) production and the reduction in pro-oxidants (e.g., heme and quinonoids, Figure 2) [14,18]

At the same time, we found that the iron content in the ovaries of chickens with atretic follicles was significantly higher than that in the non-atretic group as shown in Fig