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However, the association between high blood levels of TMAO and atherosclerosis was not observed in the Coronary Artery Risk Development in Young Adults Study (CARDIA) (52) It is not yet clear whether concentrations of choline, betaine, and/or TMAO in the blood can predict the risk for cardiovascular disease

To change monocyte and reprogram immune cells' metabolism to a pro-inflammatory situation, they used a nanoparticle approach to deliver the oligomycin, an inhibitor of OxPhos, to monocyte cells (Yamada et al