acetaminophen toxic metabolite glutathione metabolism and NAPQI-mediated mitochondrial effects How acetaminophen is metabolized in

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202,203 For instance, germline mutations in NFKB2 in non-canonical NF-B signaling affect the nuclear translocation of p52, which is thought to be the genetic cause of primary immunodeficiency syndromes

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NFB activation results in prolonged inflammation and leads to the production of numerous cytokines and mediators that can be a cause of inflammation