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This interpretation is also consistent with the clinical efficacy of liver transplantation, where replacement of the main site of TTR production reduces disease progression despite continued peripheral tissue expression of TTR

Han K, Jin X, Guo X et al (2021) Nrf2 knockout altered brain iron deposition and mitigated age-related motor dysfunction in aging mice

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In the early stages of human monocytes Mtb -infected, allicin could down-regulate the expression of Mtb ag85b gene and protein and inhibit the production of reactive oxygen species (ROS), which are through enhancing glutathione peroxidase activity, up-regulating IFN-, and inhibiting TNF- by allicin (Hasan et al., 2006, 2007), indicating that allicin has anti-inflammatory and antioxidant effects