blood-brain barrier permeation nanoparticle ligand glutathione

blood-brain barrier permeation nanoparticle ligand glutathione Strategies facilitating the of nanoparticles through barrier: An insight towards the development of brain-targeted drug delivery system Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties

Name: blood-brain barrier permeation nanoparticle ligand glutathione Strategies facilitating the of nanoparticles through barrier: An insight towards the development of brain-targeted drug delivery system Blood–Brain Barrier-Targeting Nanoparticles: Biomaterial Properties
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BloodBrain Barrier Targeting Nanoparticles: Biomaterial Properties and Biomedical Applications in Translational Neuroscience Allosteric targeted drug delivery for enhanced blood brain barrier penetration via mimicking transmembrane domain interactions Nature Communications Nanotechnology to Overcome BloodBrain Barrier Permeability and Damage in Neurodegenerative Diseases PMC Crossing the blood brain barrier: Glutathione conjugated poly(ethylene imine) for gene delivery ScienceDirect Modern methods for delivery of drugs across the bloodbrain barrier ScienceDirect

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However, high doses could lead to side effects

The toxic bioactive form of this compound 1-methyl-4-phenylpyridinium (MPP+) blocks the functioning of mitochondrial Complex-1 and NADH-ubiquinone oxidoreductase enzyme resulting in release of free electrons with concomitant ROS generation (Javitch et al., 1985)