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This contrasts with HFrEF, which primarily originates from myocardial injury (resulting from ischemia, infection, or toxicity) and neurohormonal activation, triggering cardiomyocyte apoptosis, necrosis, fibrosis, and ventricular remodeling, dominated by systolic dysfunction [40]

Although limited information exists on the exact mechanisms, recent studies suggest passive diffusion as the primary mechanism for cellular uptake of natural curcumin, including clathrin-mediated endocytosis (9698)

Higher IgA- and IgM-mediated immune responses directed against lipopolysaccharides (LPS) of certain commensal gram negative gut bacteria have been shown in depressed patients (Maes et al., 2008, 2012)

Modified radical mastectomy was performed in 304 cases (60.4%) and breast-conserving surgery plus locoregional radiotherapy in 196 cases (39%) (data available for 500 patients)