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In an imiquimod-induced PsO-like mouse model, quercetin administration significantly reduced PsO Area and Severity Index (PASI) scores, decreased skin lesion temperatures, and improved histopathological features

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In addition, anticipating the host-to-graft propagation of -syn, pathology-resistant designs, such as CRISPR-mediated SNCA knockout and dose reduction or upregulation of -syn-degrading pathways (for example, GBA1 ), offer a rational option to long-term graft functionality

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Here, cells were seeded in 96-well plates at 1,500 cells/well (for DMSO treatment) or 3,000 cells/well (for Dox, palbociclib, or Dox + palbociclib treatment)