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The p62 protein features distinct domains, including the N-terminal PB1 domain, the LC3 interaction domain, and the C-terminal UBA domain [125]

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Although IKK and IKK have contain similar structural domains and possesses 70% homology, the kinase activity of IKK towards IB is 20-50-fold higher than that of IKK [37], therefore, IKK have a higher status in activation of NF-B [38]