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Pardoll, D

doi: 10.1126/science.3029864 60 StockerRGlazerANAmesBN

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The ubiquitin ligase RNF8 initiates the ubiquitination of H2AX, and RNF168 amplifies the ubiquitination response, which triggers the recruitment of p53-binding protein 1 (53BP1) and Rap80/BRCA1 to the lesion [92, 93]