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Anisimov, Khavinson and colleagues (2003), publishing in Biogerontology , reported a lifespan study in female outbred Swiss-derived SHR mice receiving 1 g/mouse of Epitalon subcutaneously on five consecutive days each month from age three months to natural death (n = 54 per arm)

a : T 3 and b : T 4 , c and d : T 3 and T 4 at baseline (day 5) and by end of treatment (day 21), Data are shown as means SEM