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The structure of human ME2 in its binary complex with the cofactor NAD + is representative of open form I, whereas the structure of pentary complexes such as ME2-nucleotide (NAD + , NADH or ATP)-divalent cation (Mg 2+ or Mn 2+ )-substrate (pyruvate or L-malate)-fumarate is representative of closed form II of the enzyme 10,11,43

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Nerve problems, such as numbness and tingling in the hands and feet, can also occur

In addition, the secretory capacity of intestinal epithelial cells (IECs) depends on endoplasmic reticulum homeostasis

Remember, this is a process