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One commenter noted that the proposed methodology assumes that each NDC is equally responsible for driving the amount of an increase in the payment amount for the benchmark period and that the policy has the potential to assign rebate liability to a manufacturer whose individual pricing for its respective NDC(s) increased at or below the rate of inflation

Both are shaped by a mix of biological vulnerability, psychological patterns, and environmental stressors

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Kidney injury may have been a result of MTX toxicity, from volume depletion related to mucositis, but also may have been a cause, by raising MTX levels, as MTX is renally excreted